High Antiplasmodial Activity of Novel Plasmepsins I and II Inhibitors
نویسندگان
چکیده
منابع مشابه
High antiplasmodial activity of novel plasmepsins I and II inhibitors.
The aim of this study was to develop new antiplasmodial compounds acting through distinct mechanisms during both the liver and the blood stages of the parasite life cycle. Compounds were designed on the basis of the "double-drug" approach: primaquine, which has been linked to statine-based inhibitors of plasmepsins (PLMs), the plasmodial aspartic proteases involved in degradation of hemeoglobin...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2006
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm061033d